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KMID : 0861020000150020025
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Korea Journal of Herbology
2000 Volume.15 No. 2 p.25 ~ p.30
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Rhubarb Decreases Neutrophil Chemokine Production in the Skin and in the Serum Following Scald Burn Injury
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Abstract
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The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils following dermal scald burn injury. In order to inhibit the influx of neutrophils, we examined the effect of Undulati Rhubarb(R. undulatum L.) to spread on scald skin.
Dermal KC, human IL-8 family, level was elevated significantly at 24 h postburn and the level was higher at 72 h postburn than at 24 h postburn. Rhubarb markedly decreased the KC level by skin spread postburn. At 24 h postburn, KC was significantly increased in serum, Rhubarb decreased KC centent. However Rhubarb did not affect to protein concentration in serum at early stage within a 24 h postburn.
This suggests that Undulati Rhubarb should be possible to alter neutrophil accurnulation at the wound site by inhibition of the local chemokine production.
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